What GPR55 May Entail for Cannabis Receptors

The endocannabinoids in the body help to maintain balance, but the thing is, we don’t know much about whether or not there are more than just CB1 and CB2. But there is a chance that there might be another, a CB3, which can help us learn more about this. CB1 and 2 were already found in the same G protein class of receptors, the cannabinoids that bind to the other kinds of receptors in this case, also include other G proteins, one of them called receptor 55. This is remembered by the words GPR55.  The researchers call this the orphan receptor since it does have endogenous ligands that were up to this point, thought of as unknown. But to ligands do bind to the other receptors, which include anandamides. 

The researchers of this did clone and isolate this in 1999. The receptor did show up in different places within the body, where in the CBS, it was found that a lot of expression which was found in the hippocampus, was found there and in your cerebellum. The receptor was also found as well in other cells in the body, including the GI tract, spleen, and the adrenals.  The studies have also found that there were higher levels of this also found in cancer cells too. 

This has what’s called low homology, which means that it has a different structure of the other receptors, and it doesn’t share many of the same amino acids as this. But despite this difference, this is actually a receptor that deserves this title, since it does have some similarities. 

There are some studies that have looked to see the effects of this. But, without genetics and coding for the proteins, the mice won’t be able to have these same receptors as we do. But the cannabinoids do create similar effects within mice, which means that there might be other receptors that indicate these changes. 

According to a study, there was one test that was done on a bunch of plant and synthetic cannabinoids, and of course, how it interacts with GPR55.  The findings found that anandamide, 2AG, along with CBD and other kinds of molecules were able to bind as well to this. 

How this impacts Users

What does this mean for cannabis consumers? Well, what this means is that we’re able to learn a bit more about how this is applicable in the medicinal word. For instance, there are studies that explore how this can work with CBD in order to help combat the effects of epilepsy as well. 

The FDA did approve the CBD drug called epidolex for sever epilepsy, and in fact, CBD entered into the spotlight due to this, which involved anecdotes regarding children who had epileptic seizures as well.

But just because it binds to this doesn’t mean it activates it, and it actually can play the role of the antagonist, which means that it stops molecules from interacting with this. So what may happen is that CBD may not be able to work as well since the effectiveness may temporarily block those chemicals that increase the neurons that bind to this. 

There is also a chance though, that this could help with people who have IBD. This condition is associated with weight loss, fatigue, diarrhea, and pain, and there is some studies that say that if the receptor is blocked, through the antagonists, it could help to manage this, which means that CBD could be a potentially helpful tool in this. But that’s still something we don’t know the full answers to. 

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